POLARIS is a copper-binding peptide required for ethylene signalling control in Arabidopsis.
Authors: Mudge, A. M., Mehdi, S., Michaels, W. E., Oroza-Puente, B., Shen, W., Tomlinson, C., Wei, W., Hoppen, C., Uzun, B., Roy, D., Hetherington, F. M., Topping, J. F., Sadanandom, A., Groth, G., Robinson, N. J., Lindsey, K.
Date: 2025-02-04 · Version: 6
DOI: 10.1101/2023.06.15.545071 Category: Plant Biology
Model Organism: Arabidopsis thaliana
▶ AI Summary
The study reveals that the Arabidopsis POLARIS (PLS) peptide binds Cu(I) via two cysteine residues, forming a high‑affinity 1:2 complex that is essential for its biological function. PLS localizes to endomembranes and interacts with the transmembrane domain of the ethylene receptor ETR1 in a copper‑dependent manner, providing a mechanism that represses ethylene responses and is regulated by auxin and ethylene levels.
ethylene signaling copper binding POLARIS peptide ETR1 receptor Arabidopsis thaliana