Impaired methyl recycling induces substantial shifts in sulfur utilization in Arabidopsis
Authors: Tremblay, B. J.-M., Adeel, S. A., Saechao, M., Dong, Y., Andrianasolo, E., Steele, J. M., Traa, A., Yogadasan, N., Waduwara-Jayabahu, I., Katzenback, B. A., Hell, R., Wirtz, M., Moffatt, B. A.
Category: Plant Biology
Model Organism: General
▶ AI Summary
Reduced activity of methylthioadenosine (MTA) nucleosidase causes MTA over‑accumulation in reproductive tissues, leading to lowered cysteine, methionine, and S‑adenosylmethionine levels and altered sulfur and energy metabolism. These metabolic disturbances trigger misregulation of cell‑cycle progression, widespread down‑regulation of developmental genes, and genome‑wide changes in DNA methylation patterns, highlighting the extensive role of MTA recycling in plant growth and methyl‑index maintenance.