Esca Disease triggers local transcriptomic response and systemic DNA methylation changes in grapevine
Authors: Berger, M. M. J., Garcia, V., Rubio, B., Bortolami, G., Gambetta, G., Delmas, C. E. L., Gallusci, P.
Date: 2025-08-13 · Version: 1
DOI: 10.1101/2025.08.11.669596 Category: Plant Biology
Model Organism: Vitis vinifera
▶ AI Summary
The study investigated symptomatic and asymptomatic leaves of grapevines affected by esca, using metabolite profiling, RNA‑seq, and whole‑genome bisulfite sequencing. Metabolic and transcriptomic reprogramming were confined to symptomatic leaves, while DNA‑methylation changes occurred both locally and systemically, with some epigenetic marks detectable before symptoms appear, suggesting their use as early biomarkers.
esca trunk disease DNA methylation metabolite profiling RNA-seq