Single-cell-resolved calcium and organelle dynamics in resistosome-mediated cell death
Authors: Chen, Y.-F., Lin, K.-Y., Huang, C.-Y., Hou, L.-Y., Yuen, E. L. H., Sun, W.-C. J., Chiang, B.-J., Chang, C.-W., Wang, H.-Y., Bozkurt, T. O., Wu, C.-H.
Date: 2025-07-01 · Version: 1
DOI: 10.1101/2025.06.27.662017 Category: Plant Biology
Model Organism: Multi-species
▶ AI Summary
The study visualizes subcellular dynamics following activation of the NRC4 resistosome, showing that NRC4 enrichment at the plasma membrane triggers calcium influx, followed by sequential disruption of mitochondria, plastids, endoplasmic reticulum, and cytoskeleton, culminating in plasma membrane rupture and cell death. These observations define a temporally ordered cascade of organelle and membrane events that execute plant immune cell death.
NLR resistosome calcium signaling organelle disruption cell death cascade plant immunity