Introducing furanocoumarin biosynthetic genes in tomato results in coumarins accumulation and impacted growth
Authors: Bouille, A., Villard, C., Galati, G., Roumani, M., Fauvet, A., Grosjean, J., Hoengenaert, L., Boerjan, W., Ralph, J., Hilliou, F., Robin, C., Hehn, A., Larbat, R.
Date: 2025-07-08 · Version: 1
DOI: 10.1101/2025.07.07.663522 Category: Plant Biology
Model Organism: Solanum lycopersicum
▶ AI Summary
The study engineered the linear furanocoumarin pathway in tomato by integrating four biosynthetic genes, aiming to produce psoralen, but instead generated coumarins such as scopoletin. Morphophysiological, metabolomic, and transcriptomic analyses revealed that even low levels of these coumarins can influence plant growth and physiology, highlighting both benefits and costs of coumarin accumulation in crops.
metabolic engineering linear furanocoumarin pathway coumarins tomato metabolomics