Lack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stability
Authors: Salguero-Linares, J., Armengot, L., Ayet, J., Ruiz-Solani, N., Saile, S., Salas-Gomez, M., Fernandez, E., Denolf, L., Navarrete, F., Krumbach, J., Kaiser, M., Stael, S., Van Breusegem, F., Gevaert, K., Kaschani, F., petersen, m., El Kasmi, F., Valls, M., Coll, N. S.
The study demonstrates that loss of Arabidopsis metacaspase 1 (AtMC1) triggers autoimmunity reliant on downstream NLR and PRR signaling, and that overexpressing a catalytically dead AtMC1 exacerbates this effect. Overexpression of the E3 ligase SNIPER1 restores normal immunity, suggesting that AtMC1 regulates NLR protein turnover, possibly via autophagic degradation of the inactive protein.
Transcriptome responses of two Halophila stipulacea seagrass populations from pristine and impacted habitats, to single and combined thermal and excess nutrient stressors, reveal local adaptive features and core stress-response genes
Authors: Nguyen, H. M., Yaakov, B., Beca-Carretero, P., Procaccini, G., Wang, G., Dassanayake, M., Winters, G., Barak, S.
The study examined transcriptomic responses of the tropical seagrass Halophila stipulacea from a pristine and an impacted site under single and combined thermal and excess nutrient stress in mesocosms. Combined stress caused greater gene reprogramming than individual stresses, with thermal effects dominating and the impacted population showing reduced plasticity but higher resilience. Core stress‑response genes were identified as potential early field indicators of environmental stress.