NCR13 peptide protects soybean against Cercospora sojina by multiple modes of action and additive interaction with chemical fungicides
Authors: Pokhrel, A., Nath, V. S., Godwin, J., Kalunke, R., TETORYA, M., Czymmek, K. J., Shah, D. M.
Date: 2025-04-30 · Version: 1
DOI: 10.1101/2025.04.29.651315 Category: Plant Biology
Model Organism: Glycine max
▶ AI Summary
The chickpea-derived cysteine‑rich peptide NCR13_PFV1 exhibited nanomolar antifungal activity against both QoI‑sensitive and -resistant isolates of the soybean pathogen Cercospora sojina, protecting sprayed soybean leaves without phytotoxicity and showing additive effects with azoxystrobin. The peptide disrupts fungal plasma membranes, induces ROS, is rapidly internalized, binds fungal rRNA, and inhibits protein translation, with iron availability modulating its activity. These multifaceted mechanisms suggest NCR13_PFV1 as a promising bio‑fungicide for durable FLS management.
NCR13_PFV1 peptide Cercospora sojina soybean leaf spot QoI resistance reactive oxygen species