A hydrophobic core in the coiled-coil domain is essential for NRC resistosome function
Authors: Wang, H.-Y., Yuen, E. L. H., Lee, K.-T., Goh, F.-J., Bozkurt, T. O., Wu, C.-H.
Date: 2025-04-08 · Version: 2
DOI: 10.1101/2025.01.21.634219 Category: Plant Biology
Model Organism: General
▶ AI Summary
The study identifies a conserved hydrophobic core within the coiled‑coil (CC) domain of helper NLRs (NRCs) that is essential for NRC4-mediated cell death and immunity. Structural and functional analyses show that this core regulates subcellular localization, oligomerization, and phospholipid association of NRC4, highlighting a novel mechanistic feature of NLR function.
NLR coiled-coil domain hydrophobic core NRC4 plant immunity