Dual recognition of structurally unrelated mildew effectors underlies the broad-spectrum resistance of Pm3e in wheat
Authors: Kunz, L., Bernasconi, Z., Heuberger, M., Isaksson, J., Sotiropoulos, A. G., Stirnemann, U., Jigisha, J., Menardo, F., Wicker, T., Mueller, M. C., Keller, B.
Date: 2025-10-30 · Version: 2
DOI: 10.1101/2025.10.26.683672 Category: Plant Biology
Model Organism: Triticum aestivum (wheat)
▶ AI Summary
The study investigates the wheat Pm3 NLR allelic series, revealing that near-identical Pm3d and Pm3e alleles confer broad-spectrum resistance by recognizing multiple, structurally diverse powdery mildew effectors. Using chimeric NLR constructs, the authors pinpoint specificity-determining polymorphisms and demonstrate that engineered combinations of Pm3d and Pm3e further expand effector recognition, showcasing the potential for durable wheat protection through NLR engineering.
broad-spectrum resistance NLR receptors Pm3 alleles powdery mildew effectors wheat