Plant Kelch phosphatases are Ser/Thr phosphatases involved in cell cycle regulation
Authors: Rico-Resendiz, F., Pri-Tal, O., Raia, P., Moretti, A., Chen, H., Yu, J., Broger, L., Fuchs, C., Hothorn, L. A., Loubery, S., Hothorn, M.
Category: Plant Biology
Model Organism: Arabidopsis thaliana
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The study reveals that the Kelch phosphatase BSU1, previously thought to act as a tyrosine phosphatase in brassinosteroid signaling, actually functions as a PP1-like serine/threonine phosphatase whose activity is inhibited by CDK-mediated phosphorylation of its C‑terminal tail. Structural analysis, mutagenesis, and genetic experiments in Arabidopsis and Marchantia demonstrate that this regulatory mechanism links BSU1 to cell‑cycle control, affecting stomatal patterning, fertility, and undifferentiated cell mass formation.